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KMID : 1151920210030020057
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Chronobiology in Medicine
2021 Volume.3 No. 2 p.57 ~ p.59
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Clinical Utility of Polygenic Risk Score in Sleep Disorder
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Park Young-Min
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Abstract
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Recently, polygenic risk scores (PRS) using genome-wide association study (GWAS) data have attracted much attention. The present article aimed to review the literature on the relationship between sleep or sleep disorder and PRS. PRS for restless legs syndrome was a very useful marker for genetic risk and clinical characteristics. In addition, highest snoring-PRS decile had approximately twice the odds of reporting recent snoring and choking during sleep. Another study revealed that PRS for schizophrenia was associated with higher fast spindle amplitude, density, and intensity. In case of depression, REM sleep fragmentation was also associated with PRS for depressive symptoms in adolescents. Regarding bipolar disorder, the relationship between insomnia-PRS and bipolar II disorder and sleep-duration-PRS and bipolar I disorder have also been reported. Insomnia-PRS also predicted an earlier age of first cannabis use and increased the number of symptoms of cannabis use disorder. Given the small effect size in the SNP-based association, PRS is a very useful marker for clinical settings, as well as for diagnosis and treatment. In the future, PRS will be a useful tool for personalized medicine.
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KEYWORD
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Polygenic risk score, Sleep disorder, Sleep trait
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